… We included 60 subcortical vascular cognitive impairment (… AD (remaining 121 subjects
with clinically normal cognition) … , the effects of Aβ positivity or tau burden on cognitive decline …

… to measuring cerebrovascular disease burden, such as the … of our analyses may be subject
to inherent challenges with … of limiting the impact of cerebrovascular disease on cognition. …

… Aβ-positive (Aβ+) individuals could be grouped into the following … CSVD burden may have
an effect on cognitive impairment … Finally, we investigated the trajectories in cognition and MRI …

… to individuals with subcortical vascular cognitive impairment. … although individuals with MCI
or AD had higher brain Aβ burden … MCI and AD with and without cerebrovascular disease. …

… individuals without dementia [32]. Therefore, it would be reasonable to expect that the effects
of … All participants in our SVCI cohort had severe CSVD burdens, which makes it difficult to …

… These potentially additive effects of Aβ and CeVD burden … unexplored in individuals with
normal cognition or MCI. … domain-specific cognitive impairment and NPS syndromes of positron …

… Finally, instead of separating individuals into PiB+ and PiB− … the effects of Aβ and
cerebrovascular disease burden on … and examine how they might differentially affect cognition. …

… , we enrolled individuals with Alzheimer/subcortical-vascular … or signs suggestive of
cerebrovascular disease, whereas in the … with CSVD as well as Aβ burden, 38,39 which may …

… cognitive impairment. Using the previously reported PiB cutoff of 1.08 [12], we also found that
48% of all subjects were considered to have a high amyloid burden … cardiovascular disease …

… 1089 individuals aged ≥60 years with concurrent amyloid-PET … Subcortical/cortical infarctions
and lobar/deep CMBs might … impact of PC3 would be on baseline cognition and not rate of …